Unique multidomain enzymes from bacteria identified
Schematic showing the reactions catalyzed by fused radical SAM (rSAM/SPASM) and αKG-HExxH domains, found in bacterial species such as Micromonospora and Chlorogloeopsis. The radical SAM domain catalyzes cyclophane formation, while the αKG-HExxH domain catalyzes β-hydroxylation. The enzyme structure is illustrated, showcasing its distinct fold. Credit: Nature Chemistry (2024). DOI: 10.1038/s41557-024-01596-9 Pharmaceutical scientists from the National … Read more