Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention. The rapidly progressing neurodegenerative disease causes the death of neurons in the brain and spinal cord, resulting in muscle weakness, … Read more
Schematic showing the reactions catalyzed by fused radical SAM (rSAM/SPASM) and αKG-HExxH domains, found in bacterial species such as Micromonospora and Chlorogloeopsis. The radical SAM domain catalyzes cyclophane formation, while the αKG-HExxH domain catalyzes β-hydroxylation. The enzyme structure is illustrated, showcasing its distinct fold. Credit: Nature Chemistry (2024). DOI: 10.1038/s41557-024-01596-9 Pharmaceutical scientists from the National … Read more
A passage in the Norse Sverris Saga, the 800-year-old storyof King Sverre Sigurdsson, describes a military raid that occurred in AD 1197, during which a body was thrown into a well at Sverresborg Castle, outside Trondheim in central Norway, likely as an attempt to poison the main water source for the local inhabitants. A new … Read more