Coffee, rich in bioactive compounds such as caffeine, chlorogenic acids, and polyphenols, has been found to have regenerative abilities that benefit vascular health. Here’s a closer look at how caffeine contributes to these positive effects:
Modes of Action
Adenosine Receptor antagonists:
Caffeine works primarily by acting as an antagonist to adenosine receptors in the central nervous system. Adenosine normally promotes relaxation and reduces nerve activity, facilitating sleep and vasodilation. By blocking these receptors, caffeine increases nerve activity, speeds up the brain process and improves concentration12.
Calcium Release Channel Sensory:
Caffeine sensitizes Ryanodine receptor (RyR) channels, which are important for the release of calcium ions from the sarcoplasmic reticulum. Increased sensitivity causes more microscopic release of calcium, enhancing muscle strength and controlling heart rate1.
Increased Noradrenaline and Dopamine:
During exercise, caffeine increases the release of noradrenaline (NA) and dopamine (DA). Dopamine plays an important role in motivation, cognition, reward processing, motor control, and mood regulation. Enhanced DA release decreases pain perception and improves endurance performance1.
Anti-Infection Guidelines:
Apart from the ergogenic benefits during exercise, caffeine exhibits anti-inflammatory properties that are useful for neuroprotection against conditions such as Alzheimer’s disease and Parkinson’s disease. It does not alter brain-brain physiology or homeostasis but can protect the CNS from hypoxia at low doses23.
Effects on Cardiovascular Health
The anti-inflammatory and antioxidant properties of coffee compounds significantly contribute to cardiovascular health by reducing oxidative stress and inflammation associated with various diseases such as type II diabetes mellitus and sclerosis3. In particular:
Antioxidants in coffeeMore than 1000 chemical compounds are present in coffee including caffeic acid, and trigonelline which show safe effects in preventing neurodegenerative disorders.
Chlorogenic acid: This polyphenol has been shown to exert neuroprotection against rotenone-induced Parkinson’s disease through glucagon-like peptide secretion pathways3.
Conclusion
Caffeine plays an important role in improving vascular health through many mechanisms – acting as an antagonist to adenosine uptake, calcium channel sensitivity in muscle fibers during exercise – and exhibiting anti-inflammatory properties that benefit with neuroprotection against chronic diseases.
Regular consumption in moderate doses may contribute positively to the maintenance of cardiovascular health by reducing oxidative stress and inflammatory processes associated with various pathologies including cancer, neurodegenerative disorders and others making coffee an important component. is not only to enhance physical performance, but also to enhance the ability to recover in general, especially regarding the integrity of blood vessels.